Spontaneous seizure and partial lethality of juvenile Shank3-overexpressing mice in C57BL/6 J background

The SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene encodes core scaffolds in neuronal excitatory postsynapses. SHANK3 duplications have been identified in patients with hyperkinetic disorders and early-onset generalized tonic-clonic seizures. Consistently, Shank3 transgenic (TG) mice, which...

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Publicado en:Mol Brain
Autores principales: Jin, Chunmei, Zhang, Yinhua, Kim, Shinhyun, Kim, Yoonhee, Lee, Yeunkum, Han, Kihoon
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
Materias:
Micro Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180595/
https://ncbi.nlm.nih.gov/pubmed/30305163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-018-0403-6
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