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Spontaneous seizure and partial lethality of juvenile Shank3-overexpressing mice in C57BL/6 J background
The SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene encodes core scaffolds in neuronal excitatory postsynapses. SHANK3 duplications have been identified in patients with hyperkinetic disorders and early-onset generalized tonic-clonic seizures. Consistently, Shank3 transgenic (TG) mice, which...
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| Publicado en: | Mol Brain |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BioMed Central
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6180595/ https://ncbi.nlm.nih.gov/pubmed/30305163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-018-0403-6 |
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