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Thirty biologically interpretable clusters of transcription factors distinguish cancer type

BACKGROUND: Transcription factors are essential regulators of gene expression and play critical roles in development, differentiation, and in many cancers. To carry out their regulatory programs, they must cooperate in networks and bind simultaneously to sites in promoter or enhancer regions of gene...

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Dettagli Bibliografici
Pubblicato in:BMC Genomics
Autori principali: Abrams, Zachary B., Zucker, Mark, Wang, Min, Asiaee Taheri, Amir, Abruzzo, Lynne V., Coombes, Kevin R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180590/
https://ncbi.nlm.nih.gov/pubmed/30305013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-018-5093-z
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