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Topology of active, membrane-embedded Bax in the context of a toroidal pore
Bax is a Bcl-2 protein critical for apoptosis induction. In healthy cells, Bax is mostly a monomeric, cytosolic protein, while upon apoptosis initiation it inserts into the outer mitochondrial membrane, oligomerizes, and forms pores that release proapoptotic factors like Cytochrome c into the cytoso...
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| Udgivet i: | Cell Death Differ |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6180131/ https://ncbi.nlm.nih.gov/pubmed/30185826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0184-6 |
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