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Structural Model of Active Bax at the Membrane
Bax plays a central role in the mitochondrial pathway of apoptosis. Upon activation, cytosolic Bax monomers oligomerize on the surface of mitochondria and change conformation concertedly to punch holes into the outer membrane. The subsequent release of cytochrome c initiates cell death. However, the...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4869853/ https://ncbi.nlm.nih.gov/pubmed/25458844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.09.022 |
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