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Structural insights on TRPV5 gating by endogenous modulators
TRPV5 is a transient receptor potential channel involved in calcium reabsorption. Here we investigate the interaction of two endogenous modulators with TRPV5. Both phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) and calmodulin (CaM) have been shown to directly bind to TRPV5 and activate or inact...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6179994/ https://ncbi.nlm.nih.gov/pubmed/30305626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06753-6 |
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