Structural insights on TRPV5 gating by endogenous modulators

TRPV5 is a transient receptor potential channel involved in calcium reabsorption. Here we investigate the interaction of two endogenous modulators with TRPV5. Both phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) and calmodulin (CaM) have been shown to directly bind to TRPV5 and activate or inact...

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Udgivet i:Nat Commun
Main Authors: Hughes, Taylor E. T., Pumroy, Ruth A., Yazici, Aysenur Torun, Kasimova, Marina A., Fluck, Edwin C., Huynh, Kevin W., Samanta, Amrita, Molugu, Sudheer K., Zhou, Z. Hong, Carnevale, Vincenzo, Rohacs, Tibor, Moiseenkova-Bell, Vera Y.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6179994/
https://ncbi.nlm.nih.gov/pubmed/30305626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06753-6
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