Structure-based characterization of novel TRPV5 inhibitors

Transient receptor potential vanilloid 5 (TRPV5) is a highly calcium selective ion channel that acts as the rate-limiting step of calcium reabsorption in the kidney. The lack of potent, specific modulators of TRPV5 has limited the ability to probe the contribution of TRPV5 in disease phenotypes such...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Hughes, Taylor ET, Del Rosario, John Smith, Kapoor, Abhijeet, Yazici, Aysenur Torun, Yudin, Yevgen, Fluck, Edwin C, Filizola, Marta, Rohacs, Tibor, Moiseenkova-Bell, Vera Y
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6834369/
https://ncbi.nlm.nih.gov/pubmed/31647410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49572
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