SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

Puberty is regulated by epigenetic mechanisms and is highly sensitive to metabolic and nutritional cues. However, the epigenetic pathways mediating the effects of nutrition and obesity on pubertal timing are unknown. Here, we identify Sirtuin 1 (SIRT1), a fuel-sensing deacetylase, as a molecule that...

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Vydáno v:Nat Commun
Hlavní autoři: Vazquez, M. J., Toro, C. A., Castellano, J. M., Ruiz-Pino, F., Roa, J., Beiroa, D., Heras, V., Velasco, I., Dieguez, C., Pinilla, L., Gaytan, F., Nogueiras, R., Bosch, M. A., Rønnekleiv, O. K., Lomniczi, A., Ojeda, S. R., Tena-Sempere, M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6179991/
https://ncbi.nlm.nih.gov/pubmed/30305620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06459-9
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