Berberine Ameliorates High Glucose-Induced Cardiomyocyte Injury via AMPK Signaling Activation to Stimulate Mitochondrial Biogenesis and Restore Autophagic Flux

Background: Type II diabetes (T2D)-induced cardiomyocyte hypertrophy is closely linked to the impairment of mitochondrial function. Berberine has been shown to be a promising effect for hypoglycemia in T2D models. High glucose-induced cardiomyocyte hypertrophy in vitro has been reported. The present...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Hang, Weijian, He, Benhong, Chen, Jiehui, Xia, Liangtao, Wen, Bing, Liang, Tao, Wang, Xu, Zhang, Qianying, Wu, Yue, Chen, Qingjie, Chen, Juan
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6178920/
https://ncbi.nlm.nih.gov/pubmed/30337876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01121
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