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Protein S K196E mutation reduces its cofactor activity for APC but not for TFPI

BACKGROUND: Protein S (PS) is an anticoagulant molecule that functions as a cofactor for activated protein C (APC) in the inactivation of activated coagulation factors Va (FVa) and VIIIa. It also serves as a cofactor for tissue factor pathway inhibitor (TFPI) in the efficient inhibition of factor Xa...

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Vydáno v:Res Pract Thromb Haemost
Hlavní autoři: Maruyama, Keiko, Akiyama, Masashi, Miyata, Toshiyuki, Kokame, Koichi
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6178719/
https://ncbi.nlm.nih.gov/pubmed/30349894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rth2.12152
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