Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation

Protein S (PS) acts as an anticoagulant cofactor for activated protein C in regulation of blood coagulation. The K196E mutation in PS is a race-specific genetic risk factor for venous thromboembolism with a prevalence of ∼2% within the Japanese population. To evaluate the thrombosis risk of the PS-K...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Banno, Fumiaki, Kita, Toshiyuki, Fernández, José A., Yanamoto, Hiroji, Tashima, Yuko, Kokame, Koichi, Griffin, John H., Miyata, Toshiyuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635119/
https://ncbi.nlm.nih.gov/pubmed/26251307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-06-653162
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