An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo

The PI3K-AKT-mTOR-signaling pathway is frequently activated in glioblastoma (GBM). Inhibition of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta (PIK3CB)/p110β (a PI3K catalytic isoform) by RNAi substantially suppresses GBM growth with less toxicity to normal astrocytes. Howeve...

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Publicado en:Mol Ther Nucleic Acids
Autores principales: Cen, Bohong, Wei, Yuanyi, Huang, Wen, Teng, Muzhou, He, Shuai, Li, Jianlong, Wang, Wei, He, Guolin, Bai, Xin, Liu, Xiaoxia, Yuan, Yawei, Pan, Xinghua, Ji, Aimin
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Gene & Cell Therapy 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6178240/
https://ncbi.nlm.nih.gov/pubmed/30312846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.09.002
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