The N terminus and transmembrane segment S1 of Kv1.5 can coassemble with the rest of the channel independently of the S1–S2 linkage

The voltage-gated potassium channel Kv1.5 belongs to the Shaker superfamily. Kv1.5 is composed of four subunits, each comprising 613 amino acids, which make up the N terminus, six transmembrane segments (S1–S6), and the C terminus. We recently demonstrated that, in HEK cells, extracellularly applied...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Lamothe, Shawn M., Hogan-Cann, Aja E., Li, Wentao, Guo, Jun, Yang, Tonghua, Tschirhart, Jared N., Zhang, Shetuan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Membrane Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177590/
https://ncbi.nlm.nih.gov/pubmed/30121572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004065
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