The uridylyltransferase GlnD and tRNA modification GTPase MnmE allosterically control Escherichia coli folylpoly-γ-glutamate synthase FolC

Folate derivatives are important cofactors for enzymes in several metabolic processes. Folate-related inhibition and resistance mechanisms in bacteria are potential targets for antimicrobial therapies and therefore a significant focus of current research. Here, we report that the activity of Escheri...

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Publicado en:J Biol Chem
Autores principales: Rodionova, Irina A., Goodacre, Norman, Do, Jimmy, Hosseinnia, Ali, Babu, Mohan, Uetz, Peter, Saier, Milton H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177579/
https://ncbi.nlm.nih.gov/pubmed/30089654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004425
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