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Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element
MnmE, a Guanine nucleotide-binding protein conserved between bacteria and man, is involved in the modification of tRNAs. Here we provide biochemical and X-ray structural evidence for a new GTP-hydrolysis mechanism, where the G-domains of MnmE dimerise in a potassium-dependent manner and induce GTP h...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1500855/ https://ncbi.nlm.nih.gov/pubmed/16763562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601171 |
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