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Reconstitution of a thermophilic Cu(+) importer in vitro reveals intrinsic high-affinity slow transport driving accumulation of an essential metal ion
Acquisition of the trace element copper (Cu) is critical to drive essential eukaryotic processes such as oxidative phosphorylation, iron mobilization, peptide hormone biogenesis, and connective tissue maturation. The Ctr1/Ctr3 family of Cu importers, first discovered in fungi and conserved in mammal...
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| 發表在: | J Biol Chem |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6177576/ https://ncbi.nlm.nih.gov/pubmed/30131336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004802 |
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