Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells

Despite their inherent proximity to circulating oxygen and nutrients, endothelial cells (ECs) oxidize only a minor fraction of glucose in mitochondria, a metabolic specialization that is poorly understood. Here we show that the glycolytic enzyme pyruvate kinase M2 (PKM2) limits glucose oxidation, an...

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Udgivet i:Nat Commun
Main Authors: Stone, Oliver A., El-Brolosy, Mohamed, Wilhelm, Kerstin, Liu, Xiaojing, Romão, Ana M., Grillo, Elisabetta, Lai, Jason K. H., Günther, Stefan, Jeratsch, Sylvia, Kuenne, Carsten, Lee, I-Ching, Braun, Thomas, Santoro, Massimo M., Locasale, Jason W., Potente, Michael, Stainier, Didier Y. R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177464/
https://ncbi.nlm.nih.gov/pubmed/30301887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06406-8
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