The flow responsive transcription factor Klf2 is required for myocardial wall integrity by modulating Fgf signaling

Complex interplay between cardiac tissues is crucial for their integrity. The flow responsive transcription factor KLF2, which is expressed in the endocardium, is vital for cardiovascular development but its exact role remains to be defined. To this end, we mutated both klf2 paralogues in zebrafish,...

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Detalles Bibliográficos
Publicado en:eLife
Autores principales: Rasouli, Seyed Javad, El-Brolosy, Mohamed, Tsedeke, Ayele Taddese, Bensimon-Brito, Anabela, Ghanbari, Parisa, Maischein, Hans-Martin, Kuenne, Carsten, Stainier, Didier Y
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Developmental Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329608/
https://ncbi.nlm.nih.gov/pubmed/30592462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38889
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