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SYNTHESIS AND OPTICAL RESOLUTION OF HIGH AFFINITY P(2)-LIGANDS FOR HIV-1 PROTEASE INHIBITORS
Racemic bis-tetrahydrofuran ligand 6 was efficiently synthesized utilizing catalytic cobaloxime 10 mediated radical cyclization as the key step. Optical resolution of the racemic alcohol with immobilized-Amano lipase, afforded optically pure ligands.
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| Publicado no: | Tetrahedron Lett |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6177221/ https://ncbi.nlm.nih.gov/pubmed/30310245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/0040-4039(94)02296-N |
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