Novel glucosylceramide synthase inhibitor based prodrug copolymer micelles for delivery of anticancer agents

In order to improve the efficacy of chemotherapy for cancers, we have developed a novel prodrug micellar formulation to co-deliver ceramide-generating anticancer agents and ceramide degradation inhibitor (PPMP). The prodrug nanocarrier is based on a well-defined POEG-b-PPPMP diblock copolymer. The h...

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Vydáno v:J Control Release
Hlavní autoři: Xu, Jieni, Zhao, Whenchen, Sun, Jingjing, Huang, Yixian, Wang, Pengcheng, Venkataramanan, Raman, Yang, Da, Ma, Xiaochao, Rana, Ajay, Li, Song
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177216/
https://ncbi.nlm.nih.gov/pubmed/30223045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2018.09.011
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