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Enpp1 inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling
The differentiated phenotype of articular chondrocytes of synovial joints needs to be maintained throughout life. Disruption of the articular cartilage, frequently associated with chondrocyte hypertrophy and calcification, is a central feature in osteoarthritis (OA). However, the molecular mechanism...
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| Udgivet i: | Development |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Company of Biologists Ltd
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6176935/ https://ncbi.nlm.nih.gov/pubmed/30111653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.164830 |
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