Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities

The hERG (human ether-a-go-go-related gene) encoded potassium ion (K(+)) channel plays a major role in cardiac repolarization. Drug-induced blockade of hERG has been a major cause of potentially lethal ventricular tachycardia termed Torsades de Pointes (TdPs). Therefore, we presented a pharmacoinfor...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Munawar, Saba, Windley, Monique J., Tse, Edwin G., Todd, Matthew H., Hill, Adam P., Vandenberg, Jamie I., Jabeen, Ishrat
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176658/
https://ncbi.nlm.nih.gov/pubmed/30333745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01035
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