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Inhibition of cIAP1 as a strategy for targeting c-MYC–driven oncogenic activity
Protooncogene c-MYC, a master transcription factor, is a major driver of human tumorigenesis. Development of pharmacological agents for inhibiting c-MYC as an anticancer therapy has been a longstanding but elusive goal in the cancer field. E3 ubiquitin ligase cIAP1 has been shown to mediate the acti...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6176641/ https://ncbi.nlm.nih.gov/pubmed/30181285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807711115 |
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