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CRISPhieRmix: a hierarchical mixture model for CRISPR pooled screens
Pooled CRISPR screens allow researchers to interrogate genetic causes of complex phenotypes at the genome-wide scale and promise higher specificity and sensitivity compared to competing technologies. Unfortunately, two problems exist, particularly for CRISPRi/a screens: variability in guide efficien...
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| Publicat a: | Genome Biol |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6176515/ https://ncbi.nlm.nih.gov/pubmed/30296940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1538-6 |
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