The Atypical Chemokine Receptor Ackr2 Constrains NK Cell Migratory Activity and Promotes Metastasis

Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and spontaneous models. Further analysis reveals that this...

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Vydáno v:J Immunol
Hlavní autoři: Hansell, Christopher A. H., Fraser, Alasdair R., Hayes, Alan J., Pingen, Marieke, Burt, Claire L., Lee, Kit Ming, Medina-Ruiz, Laura, Brownlie, Demi, Macleod, Megan K. L., Burgoyne, Paul, Wilson, Gillian J., Nibbs, Robert J. B., Graham, Gerard J.
Médium: Artigo
Jazyk:Inglês
Vydáno: AAI 2018
Témata:
Tumor Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176105/
https://ncbi.nlm.nih.gov/pubmed/30158126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800131
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