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The N-terminal Region of the Atypical Chemokine Receptor ACKR2 Is a Key Determinant of Ligand Binding

The atypical chemokine receptor, ACKR2 is a pivotal regulator of chemokine-driven inflammatory responses and works by binding, internalizing, and degrading inflammatory CC-chemokines. ACKR2 displays promiscuity of ligand binding and is capable of interacting with up to 14 different inflammatory CC-c...

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Detalhes bibliográficos
Main Authors: Hewit, Kay D., Fraser, Alasdair, Nibbs, Robert J. B., Graham, Gerard J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007430/
https://ncbi.nlm.nih.gov/pubmed/24644289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.534545
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