Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant

OBJECTIVE: To identify the functional single‐nucleotide polymorphisms (SNPs) and mechanisms conferring increased risk of hand osteoarthritis (OA) at the ALDH1A2 locus, which is a retinoic acid regulatory gene. METHODS: Tissue samples from 247 patients with knee, hip, or hand OA who had undergone joi...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Shepherd, Colin, Zhu, Dongxing, Skelton, Andrew J., Combe, Jennifer, Threadgold, Harrison, Zhu, Linyi, Vincent, Tonia L., Stuart, Paul, Reynard, Louise N., Loughlin, John
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Osteoarthritis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175168/
https://ncbi.nlm.nih.gov/pubmed/29732726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40545
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