Single-cell dynamics determines response to CDK4/6 inhibition in triple negative breast cancer

PURPOSE: Triple negative breast cancer (TNBC) is a heterogeneous subgroup of breast cancer that is associated with poor prognosis. We evaluated the activity of CDK4/6 inhibitors across TNBC subtypes, and investigated the mechanisms of sensitivity. EXPERIMENTAL DESIGN: A panel of cell lines represent...

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Publicat a:Clin Cancer Res
Autors principals: Asghar, Uzma S., Barr, Alexis R., Cutts, Ros, Beaney, Matthew, Babina, Irina, Sampath, Deepak, Giltnane, Jennifer, Lacap, Jennifer Arca, Crocker, Lisa, Young, Amy, Pearson, Alex, Herrera-Abreu, Maria Teresa, Bakal, Chris, Turner, Nicholas C.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175044/
https://ncbi.nlm.nih.gov/pubmed/28606920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0369
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