Pharmacogenetic analysis of the UKMRC (Medical Research Council) MAGIC trial: association of polymorphisms with toxicity and survival in patients treated with perioperative epirubicin, cisplatin and 5-fluorouracil (ECF) chemotherapy

PURPOSE: Germline polymorphisms may affect chemotherapy efficacy and toxicity. We examined the effect of polymorphisms in drug metabolism and DNA repair genes on pathological response rates, survival, and toxicity for patients randomised to surgery alone or perioperative ECF chemotherapy in the MRC...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Clin Cancer Res
Autori principali: Smyth, Elizabeth, Zhang, Shenli, Cunningham, David, Wotherspoon, Andrew, Soong, Richie, Peckitt, Clare, Valeri, Nicola, Fassan, Matteo, Rugge, Massimo, Okines, Alicia, Allum, William, Stenning, Sally, Nankivell, Matthew, Langley, Ruth, Tan, Patrick
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175041/
https://ncbi.nlm.nih.gov/pubmed/28972045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-3142
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi