Mismatch Repair Deficiency, Microsatellite Instability, and Survival: An Exploratory Analysis of the Medical Research Council Adjuvant Gastric Infusional Chemotherapy (MAGIC) Trial

IMPORTANCE: Mismatch repair (MMR) deficiency (MMRD) and microsatellite instability (MSI) are prognostic for survival in many cancers and for resistance to fluoropyrimidines in early colon cancer. However, the effect of MMRD and MSI in curatively resected gastric cancer treated with perioperative che...

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Pubblicato in:JAMA Oncol
Autori principali: Smyth, Elizabeth C., Wotherspoon, Andrew, Peckitt, Clare, Gonzalez, David, Hulkki-Wilson, Sanna, Eltahir, Zakaria, Fassan, Matteo, Rugge, Massimo, Valeri, Nicola, Okines, Alicia, Hewish, Madeleine, Allum, William, Stenning, Sally, Nankivell, Matthew, Langley, Ruth, Cunningham, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Medical Association 2017
Soggetti:
Original Investigation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824280/
https://ncbi.nlm.nih.gov/pubmed/28241187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2016.6762
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