Pharmacogenetic analysis of the UKMRC (Medical Research Council) MAGIC trial: association of polymorphisms with toxicity and survival in patients treated with perioperative epirubicin, cisplatin and 5-fluorouracil (ECF) chemotherapy

PURPOSE: Germline polymorphisms may affect chemotherapy efficacy and toxicity. We examined the effect of polymorphisms in drug metabolism and DNA repair genes on pathological response rates, survival, and toxicity for patients randomised to surgery alone or perioperative ECF chemotherapy in the MRC...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Smyth, Elizabeth, Zhang, Shenli, Cunningham, David, Wotherspoon, Andrew, Soong, Richie, Peckitt, Clare, Valeri, Nicola, Fassan, Matteo, Rugge, Massimo, Okines, Alicia, Allum, William, Stenning, Sally, Nankivell, Matthew, Langley, Ruth, Tan, Patrick
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175041/
https://ncbi.nlm.nih.gov/pubmed/28972045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-3142
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