Genome mining of cyclodipeptide synthases unravels unusual tRNA-dependent diketopiperazine-terpene biosynthetic machinery

Cyclodipeptide synthases (CDPSs) can catalyze the formation of two successive peptide bonds by hijacking aminoacyl-tRNAs from the ribosomal machinery resulting in diketopiperazines (DKPs). Here, three CDPS-containing loci (dmt1–3) are discovered by genome mining and comparative genome analysis of St...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Yao, Tingting, Liu, Jing, Liu, Zengzhi, Li, Tong, Li, Huayue, Che, Qian, Zhu, Tianjiao, Li, Dehai, Gu, Qianqun, Li, Wenli
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173783/
https://ncbi.nlm.nih.gov/pubmed/30291234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06411-x
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