Deciphering a Cyclodipeptide Synthase Pathway Encoding Prenylated Indole Alkaloids in Streptomyces leeuwenhoekii

Cyclodipeptide synthases (CDPSs) catalyze the formation of cyclodipeptides using aminoacylated tRNAs as the substrates and have great potential in the production of diverse 2,5-diketopiperazines (2,5-DKPs). Genome mining of Streptomyces leeuwenhoekii NRRL B-24963 revealed a two-gene locus, saz, enco...

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Bibliographic Details
Published in:Appl Environ Microbiol
Main Authors: Zhang, Yuqiao, Yao, Tingting, Jiang, Yuechen, Li, Huayue, Yuan, Weicheng, Li, Wenli
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2021
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208138/
https://ncbi.nlm.nih.gov/pubmed/33741615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02525-20
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