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Splenectomy modulates early immuno-inflammatory responses to trauma-hemorrhage and protects mice against secondary sepsis

In polytrauma patients, the impact of splenectomy is equivocal, ranging from negative to protective. We investigated the impact of splenectomy on immune responses in the 1(st)-hit polytrauma alone and on survival in the post-traumatic sepsis (2(nd) hit). Female BALB/c mice underwent polytrauma (1(st...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Drechsler, S., Zipperle, J., Rademann, P., Jafarmadar, M., Klotz, A., Bahrami, S., Osuchowski, M. F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173732/
https://ncbi.nlm.nih.gov/pubmed/30291296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33232-1
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