A Non-Lethal Traumatic/Hemorrhagic Insult Strongly Modulates the Compartment-Specific PAI-1 Response in the Subsequent Polymicrobial Sepsis

INTRODUCTION: Plasminogen activator inhibitor 1 (PAI-1) is a key factor in trauma- and sepsis-induced coagulopathy. We examined how trauma-hemorrhage (TH) modulates PAI-1 responses in subsequent cecal ligation and puncture (CLP)-induced sepsis, and the association of PAI-1 with septic outcomes. METH...

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Main Authors: Raeven, Pierre, Salibasic, Alma, Drechsler, Susanne, Weixelbaumer, Katrin Maria, Jafarmadar, Mohammad, van Griensven, Martijn, Bahrami, Soheyl, Osuchowski, Marcin Filip
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568129/
https://ncbi.nlm.nih.gov/pubmed/23408987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055467
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