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Structural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis

Porphyromonas gingivalis is a keystone bacterial pathogen of chronic periodontitis. P. gingivalis is unable to synthesise the porphyrin macrocycle and relies on exogenous porphyrin, including haem or haem biosynthesis intermediates from host sources. We show that under the iron-limited conditions pr...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Gao, Jin-Long, Kwan, Ann H., Yammine, Anthony, Zhou, Xiaoyan, Trewhella, Jill, Hugrass, Barbara M., Collins, Daniel A. T., Horne, James, Ye, Ping, Harty, Derek, Nguyen, Ky-Anh, Gell, David A., Hunter, Neil
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173696/
https://ncbi.nlm.nih.gov/pubmed/30291238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06470-0
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