Asymmetric Entry into 10b-aza-Analogues of Amaryllidaceae Alkaloids Reveals a Pronounced Electronic Effect on Antiviral Activity

[Image: see text] Development of a chiral pool-based synthesis of 10b-aza-analogues of biologically active Amaryllidaceae alkaloids is described, involving a concise reductive amination and condensation sequence, leading to ring-B/C-modified, fully functionalized ring-C derivatives. Differentiated a...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Brown, Carla E., Kong, Tiffany, Britten, James F., Werstiuk, Nick H., McNulty, James, D’Aiuto, Leonardo, Demers, Matthew, Nimgaonkar, Vishwajit L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173499/
https://ncbi.nlm.nih.gov/pubmed/30320263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b01987
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