CYCLIC SULFONE-3-CARBOXAMIDES AS NOVEL P(2)-LIGANDS FOR Ro 31-8959 BASED HIV-1 PROTEASE INHIBITORS

Cyclic sulfone-3-carboxamides are effective P(2)-1igands for HIV-1 protease inhibitors. Incorporation of 3S-tetrahydro-2H-thiopyrancarboxamide-l, l-dioxide in the hydroxyethylamine series resulted in inhibitor 14 (IC(50)=9 nM, CIC(95)=200 nM) with improved potency compared to its corresponding ureth...

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Enregistré dans:
Détails bibliographiques
Publié dans:Bioorg Med Chem Lett
Auteurs principaux: Ghosh, Arun K., Thompson, Wayne J., Munson, Peter M., Liut, Wenming, Huff, Joel R.
Format: Artigo
Langue:Inglês
Publié: 2000
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173326/
https://ncbi.nlm.nih.gov/pubmed/30294073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/0960-894X(94)00463-P
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