Inhibition of p75 neurotrophin receptor does not rescue cognitive impairment in adulthood after isoflurane exposure in neonatal mice

BACKGROUND: Isoflurane is widely used for anaesthesia in humans. Isoflurane exposure of rodents prior to post-natal day 7 (PND7) leads to widespread neurodegeneration in laboratory animals. Previous data from our laboratory suggest an attenuation of apoptosis with the p75 neurotrophin receptor (p75N...

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Detalhes bibliográficos
Publicado no:Br J Anaesth
Main Authors: Schilling, J.M., Kassan, A., Mandyam, C., Pearn, M.L., Voong, A., Grogman, G.G., Risbrough, V.B., Niesman, I.R., Patel, H.H., Patel, P.M., Head, B.P.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Neurosciences and Neuroanaesthesia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6172965/
https://ncbi.nlm.nih.gov/pubmed/28969308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bja/aew299
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