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Isoflurane Neurotoxicity Is Mediated by p75(NTR)-RhoA Activation and Actin Depolymerization
BACKGROUND: The mechanisms by which isoflurane injured the developing brain are not clear. Recent work has demonstrated that it is mediated in part by activation of p75 neurotrophin receptor (p75(NTR)). p75(NTR) activates RhoA, a small GTPase that can depolymerize actin. It is therefore conceivable...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3037980/ https://ncbi.nlm.nih.gov/pubmed/21169791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e318201dcb3 |
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