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Isoflurane Neurotoxicity Is Mediated by p75(NTR)-RhoA Activation and Actin Depolymerization

BACKGROUND: The mechanisms by which isoflurane injured the developing brain are not clear. Recent work has demonstrated that it is mediated in part by activation of p75 neurotrophin receptor (p75(NTR)). p75(NTR) activates RhoA, a small GTPase that can depolymerize actin. It is therefore conceivable...

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Bibliografiske detaljer
Main Authors: Lemkuil, Brian P., Head, Brian P., Pearn, Matthew L., Patel, Hemal H., Drummond, John C., Patel, Piyush M.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037980/
https://ncbi.nlm.nih.gov/pubmed/21169791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e318201dcb3
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