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Calcineurin B homologous protein 3 binds with high affinity to the CHP binding domain of the human sodium/proton exchanger NHE1

The Na(+)/H(+) exchanger NHE1 is critical for cell vitality as it controls intracellular pH and cell volume. Its functionality is influenced by calcineurin B homologous proteins (CHPs). The human isoform CHP3 is important for transport of NHE1 to the plasma membrane and for its activity. Here, we ch...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Fuchs, Simon, Hansen, Sierra C., Markones, Marie, Mymrikov, Evgeny V., Heerklotz, Heiko, Hunte, Carola
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6172220/
https://ncbi.nlm.nih.gov/pubmed/30287853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33096-5
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