Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastoma

Despite the identification of MYCN amplification as an adverse prognostic marker in neuroblastoma, MYCN inhibitors have yet to be developed. Here, by integrating evidence from a whole-genome shRNA library screen and the computational inference of master regulator proteins, we identify transcription...

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Bibliografske podrobnosti
izdano v:Oncogene
Main Authors: Boboila, Shuobo, Lopez, Gonzalo, Yu, Jiyang, Banerjee, Debarshi, Kadenhe-Chiweshe, Angela, Connolly, Eileen P., Kandel, Jessica J., Rajbhandari, Presha, Silva, Jose M., Califano, Andrea, Yamashiro, Darrell J.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6172192/
https://ncbi.nlm.nih.gov/pubmed/29880876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0326-9
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