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Modulating enzyme activity by altering protein dynamics with solvent

Optimal enzyme activity depends on a number of factors, including structure and dynamics. The role of enzyme structure is well recognized, however, the linkage between protein dynamics and enzyme activity has given rise to a contentious debate. We have developed an approach that uses an aqueous mixt...

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Foilsithe in:Biochemistry
Main Authors: Duff, Michael R., Borreguero, Jose M., Cuneo, Matthew, Ramanathan, Arvind, He, Junhong, Kamath, Ganesh, Chennubhotla, Chakra, Meilleur, Flora, Howell, Elizabeth E., Herwig, Kenneth W., Myles, Dean A. A., Agarwal, Pratul K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6172137/
https://ncbi.nlm.nih.gov/pubmed/29901984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00424
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