Differential Effects of Inhibitory and Stimulatory Anti-HER2 Monoclonal Antibodies on AKT/ERK Signaling Pathways

OBJECTIVE: Homo- and heterodimerization of the receptor tyrosine kinase HER2 hyperactivate several downstream signaling pathways, leading to uncontrolled growth and proliferation of tumor cells. Anti-HER2 monoclonal antibodies (mAbs) may induce different effects on HER2 dimerization and signaling. M...

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Pubblicato in:Asian Pac J Cancer Prev
Autori principali: Soltantoyeh, Tahereh, Bahadori, Tannaz, Hosseini-Ghatar, Reza, Khoshnoodi, Jalal, Roohi, Azam, Mobini, Maryam, Golsaz-Shirazi, Forough, Jeddi-Tehrani, Mahmood, Amiri, Mohammad Mehdi, Shokri, Fazel
Natura: Artigo
Lingua:Inglês
Pubblicazione: West Asia Organization for Cancer Prevention 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6171393/
https://ncbi.nlm.nih.gov/pubmed/30139234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22034/APJCP.2018.19.8.2255
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