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Differential Effects of Inhibitory and Stimulatory Anti-HER2 Monoclonal Antibodies on AKT/ERK Signaling Pathways
OBJECTIVE: Homo- and heterodimerization of the receptor tyrosine kinase HER2 hyperactivate several downstream signaling pathways, leading to uncontrolled growth and proliferation of tumor cells. Anti-HER2 monoclonal antibodies (mAbs) may induce different effects on HER2 dimerization and signaling. M...
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| Vydáno v: | Asian Pac J Cancer Prev |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
West Asia Organization for Cancer Prevention
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6171393/ https://ncbi.nlm.nih.gov/pubmed/30139234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22034/APJCP.2018.19.8.2255 |
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