Mechanism of Fibrosis in HNF1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease

BACKGROUND: Mutation of HNF1B, the gene encoding transcription factor HNF-1β, is one cause of autosomal dominant tubulointerstitial kidney disease, a syndrome characterized by tubular cysts, renal fibrosis, and progressive decline in renal function. HNF-1β has also been implicated in epithelial–mese...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Am Soc Nephrol
Päätekijät: Chan, Siu Chiu, Zhang, Ying, Shao, Annie, Avdulov, Svetlana, Herrera, Jeremy, Aboudehen, Karam, Pontoglio, Marco, Igarashi, Peter
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Nephrology 2018
Aiheet:
Basic Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6171276/
https://ncbi.nlm.nih.gov/pubmed/30097458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018040437
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