YAP Tyrosine Phosphorylation and Nuclear Localization in Cholangiocarcinoma Cells is Regulated by LCK and Independent of LATS Activity

The hippo pathway effector, Yes-associated protein (YAP) is a transcriptional co-activator implicated in cholangiocarcinoma (CCA) pathogenesis. YAP is known to be regulated by a serine/threonine kinase relay module (MST1/2 - LATS1/2) culminating in phosphorylation of YAP at Serine 127 (S127) and cyt...

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Detaylı Bibliyografya
Yayımlandı:Mol Cancer Res
Asıl Yazarlar: Sugihara, Takaaki, Werneburg, Nathan W., Hernandez, Matthew C., Yang, Lin, Kabashima, Ayano, Hirsova, Petra, Yohanathan, Lavanya, Sosa, Carlos, Truty, Mark J., Vasmatzis, George, Gores, Gregory J., Smoot, Rory L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170676/
https://ncbi.nlm.nih.gov/pubmed/29903769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-0158
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