The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes

Activation-induced cytidine deaminase (AID) mediates class switching by binding to a small fraction of single-stranded DNA (ssDNA) to diversify the antibody repertoire. The precise mechanism for highly selective AID targeting in the genome has remained elusive. Here, we report an RNA-binding protein...

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Publié dans:Cell Res
Auteurs principaux: Chen, Juan, Cai, Zhaokui, Bai, Meizhu, Yu, Xiaohua, Zhang, Chao, Cao, Changchang, Hu, Xihao, Wang, Lei, Su, Ruibao, Wang, Di, Yao, Yingpeng, Ye, Rong, Hou, Baidong, Yu, Yang, Yu, Shuyang, Li, Jinsong, Xue, Yuanchao
Format: Artigo
Langue:Inglês
Publié: Springer Singapore 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170407/
https://ncbi.nlm.nih.gov/pubmed/30143796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-018-0076-9
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