Insulin regulates POMC neuronal plasticity to control glucose metabolism

Hypothalamic neurons respond to nutritional cues by altering gene expression and neuronal excitability. The mechanisms that control such adaptive processes remain unclear. Here we define populations of POMC neurons in mice that are activated or inhibited by insulin and thereby repress or inhibit hep...

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Udgivet i:eLife
Main Authors: Dodd, Garron T, Michael, Natalie J, Lee-Young, Robert S, Mangiafico, Salvatore P, Pryor, Jack T, Munder, Astrid C, Simonds, Stephanie E, Brüning, Jens Claus, Zhang, Zhong-Yin, Cowley, Michael A, Andrikopoulos, Sofianos, Horvath, Tamas L, Spanswick, David, Tiganis, Tony
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2018
Fag:
Human Biology and Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170188/
https://ncbi.nlm.nih.gov/pubmed/30230471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38704
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