Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance

The importance of hypothalamic insulin signaling on feeding and glucose metabolism remains unclear. We report that insulin acts on AgRP neurons to acutely decrease meal size and thereby limit postprandial glucose and insulin excursions. The promotion of insulin signaling in AgRP neurons decreased me...

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Bibliographische Detailangaben
Veröffentlicht in:Sci Adv
Hauptverfasser: Dodd, Garron T., Kim, Seung Jae, Méquinion, Mathieu, Xirouchaki, Chrysovalantou E., Brüning, Jens C., Andrews, Zane B., Tiganis, Tony
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2021
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7909880/
https://ncbi.nlm.nih.gov/pubmed/33637536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf4100
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